Pathways of Colorectal Carcinogenesis - PMC - National Center …
WEBAdenoma–Carcinoma Sequence. Most colorectal tumors arise from pre-cancerous polyps that are broadly categorized as either traditional tubular adenomas or serrated polyps. Adenomas develop when normal mechanisms that regulate DNA repair and cell proliferation are altered.
The Adenoma-Carcinoma Sequence, Management, and Treatment of Colon Cancer
WEBNov 30, 2023 · Colorectal cancer (CRC) is a leading cause of death, worldwide. Most sporadic cancers arise from the adenoma-carcinoma pathway. This pathway, together with the serrated polyp-carcinoma sequence, constitute 95% of cancer of the colon. The hereditary CRC syndromes represent 5% of colon cancers.
Single-cell transcriptomic profiling unravels the adenoma …
WEBFeb 28, 2022 · The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer. However, cellular heterogeneity in aberrant epithelial cells limits our...
colorectal adenoma–carcinoma sequence - Oxford Academic
WEBNov 5, 2002 · It is widely accepted that the adenoma–carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.
The Adenoma-carcinoma Sequence in Colorectal Neoplasia
WEBIn this article the epidemiologic, pathologic, molecular, and clinical evidence for the adenoma-carcinoma sequence is reviewed. The authors describe the morphologic evolution of the precursor adenomas, from the earliest discernible abnormality of the colon to adenomas with advanced pathologic features, the factors that determine the risk of ...
Elucidating immunological characteristics of the adenoma-carcinoma ...
WEBMay 2, 2024 · Most CRC develops from advanced colorectal adenoma (ACA), a precancerous stage, through the adenoma-carcinoma sequence. However, its underlying mechanisms, including how the tumor...
The colorectal adenoma-carcinoma sequence - PubMed
WEBResults: The evidence supporting the adenoma-carcinoma sequence can be classified as epidemiological, clinicopathological and genetic. The most recent and largest body of data relates to molecular genetic events and their cellular effects; however, many other approaches, such as cytogenetics, molecular cytogenetics and cytometry, have also ...
WEBThe adenoma-carcinoma sequence is a concept that envisages the evolution of carcinoma of the colon and rectum by way of an intermediate benign entity, the adenoma. It is a hypothesis that is as time honored as any in medical science.
Mutational analysis of driver genes defines the colorectal adenoma…
WEBFeb 16, 2022 · Molecular alterations that play a role in the initiation and progression of CRC suggest a heterogeneous adenoma-carcinoma sequence that comprises several distinct molecular pathways.
The molecular genetics of colorectal cancer - Frontline …
WEBHas awareness of the molecular genetics of colorectal carcinogenesis and the adenoma-carcinoma sequence. Knows the range of predisposing conditions, including inherited syndromes and acquired colonic diseases.
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