Alzheimer's: Boosting brain protein may slow cognitive decline
WEB3 days ago · Share on Pinterest New research looks into the role of amyloid-beta in developing Alzheimer’s. Westend61/Getty Images A main theory behind the cause of Alzheimer’s disease is the build-up of ...
Immune cells key in blood vessel damage, neurodegeneration
WEB2 days ago · This triggers a chain reaction that damages blood vessels, preventing them from clearing amyloid, which leads to degeneration of brain tissue. In their latest study, the researchers show that pre-clinical models genetically engineered to express the human ApoE4 variant developed impaired blood vessels and tissue damage in their brains, while ...
Understanding changes in pre-clinical Alzheimer's disease: Study …
WEB3 days ago · Amyloid-beta and tau proteins have long been associated with Alzheimer's disease. The pathological buildup of these proteins leads to cognitive decline in people with the disease. How it does that ...
New Treatment Reverses Alzheimer’s Disease Signs
WEBDec 20, 2023 · Both early-life and middle-age treatment showed signs of inhibiting the process that forms the most prominent protein aggregates in Alzheimer’s, known as amyloid beta plaques. For the later treatment, not only the underlying process but also the amyloid plaque numbers themselves were reduced.
Blood test can predict presence of beta-amyloid in the brain, new …
WEBFeb 17, 2022 · A new blood test that predicts amyloid plaques in the brain shows promise as a cost-effective, noninvasive alternative to brain imaging and spinal tap tests, an NIA-funded study finds.
Study suggests treatments that unleash immune cells in the brain …
WEBApr 30, 2024 · In a study, an antibody treatment blocked interaction between APOE proteins and LILRB4 receptors in the brain, enabling microglia immune cells to clear amyloid plaques, a feature of Alzheimer’s. Credit: Donny Bliss/NIH.
New culprit in amyloid beta buildup, neurodegeneration
WEBNov 8, 2023 · Researchers at Weill Cornell Medicine have demonstrated how amyloid beta, a peptide associated with Alzheimer’s disease, can interact with a protein receptor on immune cells in the brain. This triggers a reaction that damages blood vessels and causes neurodegeneration.
FDA Converts Novel Alzheimer’s Disease Treatment to Traditional ...
WEBLeqembi is the first amyloid beta-directed antibody to be converted from an accelerated approval to a traditional approval for the treatment of Alzheimer’s disease. The drug works by reducing...
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
WEBAug 30, 2021 · Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology.
The amyloid hypothesis in Alzheimer disease: new insights from …
WEBFeb 17, 2022 · Soluble oligomeric Aβ and deposited Aβ in amyloid plaques interact with microglia, astroglia, blood vessels and neurons to induce various damaging cellular responses that ultimately lead to...
Skip to content