Previous captain Jamie George has been ruled out of Englands first Six Nations; The England squad has been hit by five injuries including Georges after the weekends club matches and new players have been called up;

Hooker George, who has been replaced by Maro Itoje as captain, suffered a hamstring injury playing for Saracens in the Champions Cup and is among a group of five forced to withdraw from a pre-tournament training camp in Girona.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.