On Sunday, the 49ers couldn't rob the Rams of hope. The trick now is to get it together fast enough so they don't lose their ...

With Christian McCaffrey, Deebo Samuel and George Kittle already sidelined against the Los Angeles Rams, the injury bug ...

Head coach Kyle Shanahan recapped the team's 27-24 loss to the Los Angeles Rams and evaluated the team's performance in Week ...

Christian McCaffrey has been absent for the San Francisco 49ers so far this season, having been hit by Achilles tendinitis.

The last time the Los Angeles Rams and San Francisco 49ers met, head coaches Sean McVay and Kyle Shanahan were without some ...

Running back Isaac Guerendo is fast. And he's big. But the San Francisco 49ers rookie is a work in progress. His lone carry ...

The San Francisco 49ers head to Southern California to take on the division-rival Los Angeles Rams on Sunday. They do so with ...

There may not be two teams more injured than the Los Angeles Rams and San Francisco 49ers, which will have a big impact on ...

The San Francisco 49ers suddenly have a host of injury problems, and it's reflected on their second practice report of ...

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

Given that the calf strain to 49ers running back Christian McCaffrey suddenly and unexpectedly became an Achilles tendon, too ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...